Compilation of Drugs involved in specific conditions (1)

1. Drugs that may increase the risk of neurotoxicity by Lithium:

  • Diuretics (esp. thiazides),
  • ACEI/ ARBs
  • Diltiazem or verapamil

2. Drugs that can be cleared with haemodialysis – mnemonic: BLAST

  • arbiturate
  • ithium
  • lcohol (inc methanol, ethylene glycol)
  • alicylates
  • heophyllines (charcoal haemoperfusion is preferable)
 Drugs which cannot be cleared with haemodialysis include
  • tricyclics
  • benzodiazepines
  • dextropropoxyphene (Co-proxamol) – opioid analgesic
  • digoxin
  • beta-blockers
3. Drugs apparently safe in breast feeding:

  • antibiotics: penicillins, cephalosporins, trimethoprim
  • endocrine: glucocorticoids (avoid high doses), levothyroxine*
  • epilepsy: sodium valproate, carbamazepine
  • asthma: salbutamol, theophyllines
  • psychiatric drugs: tricyclic antidepressants, antipsychotics**
  • hypertension: beta-blockers, hydralazine, methyldopa
  • anticoagulants: warfarin, heparin
  • digoxin
Drugs that should be avoided in breast feeding:

  • antibiotics: ciprofloxacin, tetracycline, chloramphenicol, sulphonamides
  • psychiatric drugs: lithium, benzodiazepines
  • aspirin
  • carbimazole
  • sulphonylureas
  • cytotoxic drugs
  • amiodarone

*the BNF advises that the amount is too small to affect neonatal hypothyroidism screening
**clozapine should be avoided

 
4. Drug causing oculogyric crisis :

  1. phenothiazines
  2. haloperidol
  3. metoclopramide
  4. postencephalitic Parkinson’s disease

5. Acute intermittent Porphyria (AIP)

a. Drugs which may precipitate attack

  • barbiturates
  • benzodiazepines
  • halothane
  • alcohol
  • oral contraceptive pill
  • sulphonamides
b. Drugs considered safe to use

  • paracetamol
  • aspirin
  • codeine
  • morphine
  • chlorpromazine
  • beta-blockers
  • penicillin
  • metformin
Unsafe/ High risk/ To avoid :
  • Arsine
  • Chloramphenicol
  • Chloroquine, Primaquine, Pamaquine, Pentaquine
  • Ciprofloxacin
  • Probenecid
  • Dapsone
  • Dimercaprol
  • Doxorubicin
  • Furazolidone
  • Glibenclamide
  • Glucosulfone
  • Isobutyl Nitrite
  • Menadiol (Vit K3, K4)
  • Mesalazine (5-ASA), O-ASA
  • Metamizole
  • Methylene Blue
  • Nalidixic acid
  • Nitrofurantoin
  • Naphtalene
  • Urate Oxidase
  • Phenacetin
  • phenazopyridine
  • Phenylhydrazine
  • Sulfamethoxazole, Sulfasalazine, Sulfapyridine
Low-risk drugs which can probably be given in NORMAL THERAPEUTIC DOSES to G-6-PD-deficient subjects without nonspherocytic hemolytic anemia
  • Acetaminophen (paracetamol, Tylenol, Tralgon, hydroxyacetanilide)
  • Acetophenetidin (phenacetin)
  • Aminopyrine (Pyramidon, amidopyrine)
  • Antazoline (Antistine)
  • Antipyrine
  • Ascorbic acid (vitamin C)
  • Benzhexol (Artane)
  • Chloramphenicol [high risk for Mediterranean and Asian variants]
  • Chlorguanidine (Proguanil, Paludrine)
  • Chloroquine
  • Colchicine
  • Diphenhydramine (Benadryl)
  • Isoniazid
  • L-Dopa
  • Menadione sodium bisulfite (Hykinone)
  • Menapthone
  • p-Aminobenzoic acid
  • Phenylbutazone
  • Phenytoin
  • Probenecid (Benemid)
  • Procain amide hydrochlonde (Pronestyl)
  • Pyrimethamine (Daraprim)
  • Quinidine
  • Quinine
  • Streptomycin
  • Sulfacytine
  • Sulfadiazine
  • Sulfaguanidine
  • Sulfamerazine
  • Sulfamethoxypyridazine (Kynex)
  • Sulfisoxazole (Gantrisin)
  • Trimethoprim
  • Tripelennamine (pyribenzamine)
  • Vitamin K
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