Polycythemia

Polycythemia

Primary polycythemia/ Polycythemia vera

  • a.k.a polycythemia rubra vera; erythremia
  • common in age 60 – 75
  • overproduction of all three hematopoietic cell lines with predominant elevation in red cell counts
  • mutation in the JAK2 protein which regulates marrow production
  • red cells grow wildly despite a Low erythropoietin level
  • high serum leukocyte alkaline phosphate
features:
  • Headache, blurred vision, and tinnitus
  • pruritus, especially after hot bath (due to histamine release from increased numbers of basophils)
  • HTN, facial plethora, fatigue, Splenomegaly
  • Bleeding from engorged blood vessels
  • Thrombosis from hyperviscosity
Investigation,
  • elevated Hct >60%*
  • low MCV and Low iron (because of excessive usage and production)
  • however, Vit. B12 levels are elevated for unclear reason
  • exclude hypoxia first; normal Oxygen level and *low erythropoietin level in PV
* RCC also has elevated Hct, but the erythropoietin is elevated.
* A small number of patients can convert to AML.
Tx
  • initial 1st line – Phlebotomy and aspirin prevent thrombosis – target Hct 45%
  • Hydroxyurea helps lower the cell count
    • indicated in old age >70 years; has thrombosis; has a platelet count >1500; and has cardiovascular risk factors
  • Allopurinol or rasburicase protects against uric acid rise
  • Antihistamines
  • Interferon alpha may be used in refractory cases
Platelet counts elevate temporarily after spleen removal

Secondary polycythemia
Increased erythropoietin level
2° to chronic tissue hypoxia
 

Kidney cancer is an important differential diagnosis of secondary polycythemia.

Renal Cell Carcinoma is a neoplastic condition that can initially appear with many different paraneoplastic manifestations.

The initial presentation may include hypertension, flank mass, gross or microscopic hematuria, hypercalcemia, fever, weight loss, and/or polycythemia.

Polycythemia may be the presenting sign in 3% of cases of kidney cancer.

Careful evaluation is important in patients presenting with polycythemia and hematuria.

Polycythemia is secondary to a hypersecretion of tumor cytokines, including renin.

The patient’s erythropoietin level is usually high.

Surgical removal of the cancer resolves the polycythemia.

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What blood group you are ?

Does anybody aware of the fact that your blood group itself is a minor risk factor for certain type of diseases?

Here it comes –

  1. Individuals with blood groups A, B, or AB were 5% to 23% more likely to develop coronary heart disease compared with subjects with O blood type, and the associations were not altered by multivariate adjustment of other risk or dietary factors. (The analysis, led by Dr Meian He (Harvard School of Public Health, Boston, MA), included 62 073 women from the Nurses’ Health Study (NHS) and 27 428 men from the Health Professionals Follow-up Study (HPFS) and is published in the September 2012 issue of Arteriosclerosis, Thrombosis, and Vascular Biology.)
  2. Rotavirus (that causes diarrhea) has certain strains which are more likely to infect people with blood type A.
  3. People with type B blood have a 72 percent increased risk of pancreatic cancer, and the risk is also elevated for AB blood types (51 percent) and those with blood type A (32 percent) compared to people with blood type O, according to a study published in the Journal of the National Cancer Institute.
  4. For the women with blood type A and AB seeking fertility treatments—research shows they have more eggs in their ovaries than women with type O blood, who are more likely to have difficulty with fertility treatments.
  5. People with type A blood appeared to have higher incidences of breast cancer and lung cancer, blood types B and O were more likely to suffer from gastrointestinal cancer, and people with type B and A blood had higher incidents of oral cancer. In general, those with blood type A seemed to have an increases probability of getting cancer, and those with blood type O had a significantly lower risk.
  6. Patients with blood Group A have a higher chance to develop gastric cancer while those with Group O can easily get Peptic ulcer disease especially duodenal ulcer.

Well, I am group A and all those researches are saying I am more likely to get coronary heart disease, diarrhea and some GI tract cancers than any other blood types! And as you all know, doctors, especially junior doctors, are prone to get gastritis and heart problems  because of the nature of the work, stress and duty hours. It shocked me. Since this is  a non-modifiable risk factor, all I can do is to reduce the other risk factors such as smoking, heavy drinking, unhealthy eating habit and sedentary life style and finally, of course, to pray.
What about you?

 

Source:

http://health.yahoo.net/experts/dayinhealth/what-your-blood-type-reveals-about-your-health

http://www.ncbi.nlm.nih.gov/pubmed/20937632